The main ingredient in Capsipure comes from the patent pending blend from Capsimax Plus which is a proprietary blend containing Capsimax Capsicum Extract, Caffeine, Piperine (Black Pepper Extract) and Niacin. In a double bind, randomized, placebo controlled cross-over study undertaken at a University in USA, 25 subjects exercised on a treadmill on two occasions. On one occasion, subjects took Capsimax Plus 60-minutes before exercise and on the second occasion they took a placebo. When the subjects took Capsimax Plus, they burned an average cumulative total of 278 more calories combined before, during and after exercise compared to placebo.Several studies have found that the addition of capsaicinoids to the diet causes a reduction in ad libitum energy intake during subsequent meals in other words, eating Capsicum at breakfast causes a person to eat fewer calories at lunch. A dramatic example of hot peppers appetite-suppressing capability is illustrated by a 2001 study published in the British Journal of Nutrition (Yoshioka 2001). When subjects ate 22 grams of hot pepper, providing 66 mg of capsaicinoids, plus 800 mg of caffeine spread out over a 24-hour period, they had a negative energy balance of 956 kilocalories compared to the placebo group.
