Vitamin B-6 refers to a family of three closely-related, water soluble compounds: Pyridoxine, Pyridoxal and Pyridoxamine. The conversion of Vitamin B-6 into the active compound of Pyridoxal-5-Phosphate requires the presence of Vitamin B-2 and Magnesium; another example of the interrelationship of the B Vitamins. Pyridoxine (Vitamin B-6) is often taken by women as a Pre-menstrual supplement to assist essential fatty acid metabolism and fluid balance. Vitamin B-6 levels have been shown to be lower in those with Atherosclerosis and Cardiovascular Disease.